Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting
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چکیده
منابع مشابه
LIMP-2 Is a Receptor for Lysosomal Mannose-6-Phosphate-Independent Targeting of β-Glucocerebrosidase
beta-glucocerebrosidase, the enzyme defective in Gaucher disease, is targeted to the lysosome independently of the mannose-6-phosphate receptor. Affinity-chromatography experiments revealed that the lysosomal integral membrane protein LIMP-2 is a specific binding partner of beta-glucocerebrosidase. This interaction involves a coiled-coil domain within the lumenal domain. beta-glucocerebrosidase...
متن کاملInsulin-like growth factor II/cation-independent mannose 6-phosphate receptor and lysosomal enzyme recognition.
I36 1 1 Chao, H. H.-J., Waheed, A., Polhmann, R., Hille, A. and von Figura, K. (1990) EMBO J. 9, 3507-3513 12 Ma, Z., Grubb, J. H. and Sly, W. S. (1991) J. Biol. Chem. 266, 10589-10595 13 Johnson, K. F. and Kornfeld, S. (1992) J. Biol. Chem. 267, 17110-17113 14 Ludwig, T., Ruther, U., Metzger, R., Copeland, N. G., Jenkins, N. A., Lobel, P. and Hoflack, B. (1992) J. Biol. Chem. 267, 1221 1-12219...
متن کاملMannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.
The lysosomal integral membrane protein type 2 (LIMP-2/SCARB2) has been described as a mannose 6-phosphate (M6P)-independent trafficking receptor for β-glucocerebrosidase (GC). Recently, a putative M6P residue in a crystal structure of a recombinantly expressed LIMP-2 ectodomain has been reported. Based on surface plasmon resonance and fluorescence lifetime imaging analyses, it was suggested th...
متن کاملMannose 6-phosphate-independent targeting of lysosomal enzymes in I- cell disease B lymphoblasts
B lymphocytes from patients with I-cell disease (ICD) maintain normal cellular levels of lysosomal enzymes despite a deficiency of the enzyme UDP-N-acetylglucosamine: lysosomal enzyme N-acetylglucosamine-1-phosphotransferase. We find that an ICD B lymphoblastoid cell line targets about 45% of the lysosomal protease cathepsin D to dense lysosomes. This targeting occurs in the absence of detectab...
متن کاملMannose 6-Phosphate-independent Targeting of Lysosomal Enzymes in I-CeU Disease B Lymphoblasts
ease (ICD) maintain normal cellular levels of lysosomal enzymes despite a deficiency of the enzyme UDP-N-acetylglucosamine: lysosomal enzyme N-acetylglucosamine-l-phosphotransferase. We find that an ICD B lymphoblastoid cell line targets about 45 % of the lysosomal protease cathepsin D to dense lysosomes. This targeting occurs in the absence of detectable mannose 6-phosphate residues on the cat...
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ژورنال
عنوان ژورنال: Traffic
سال: 2015
ISSN: 1398-9219
DOI: 10.1111/tra.12284